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For cytosolic folate variables and methionine cycle variables, see the discussions in our previous papers [1621]

503 Despite these advances, the use of first- and second-generation mTOR inhibitors has been associated with a range of side effects such as insulin resistance, hyperglycemia, impaired wound healing, hypertension, and various metabolic, renal, and pulmonary complications

doi: 10.2337/db18-0933

Gut 52 , 439451 (2003)

Pharmaceutics 14 , 2728 (2022)