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Furthermore, subsequent addition of the complex I inhibitor rotenone entirely blocked NADH oxidation and caused a potentiation in H 2 O 2 production after mitochondrial membrane potential was collapsed by addition of FCCP (95), indicating that a high NADH level is crucial for ROS production at complex I

All intermediates and final products were characterized using 1 H NMR spectroscopy, 13 C NMR spectroscopy, and high-resolution mass spectrometry (Supplementary Figs

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Finney-Brown T

We then examine therapeutic innovations targeting proteostasis, including chaperone modulators, proteostasis pathway inhibitors, and emerging strategies to increase proteome resilience