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[DOI] [PMC free article] [PubMed] [Google Scholar] Eijkelenboom A, Burgering BM

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W.Advances in Medicinal Chemistry

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Drugs that are completely retained within the vascular compartment, on the other hand, would have a minimum possible volume of distribution equal to the blood component in which they are distributed, eg, 0.04 L/kg body weight or 2.8 L/70 kg ( Table 32 ) for a drug that is restricted to the plasma compartment

In contrast to oncogene addiction, the inappropriate activation of c-MET resulting in oncogene expedience is the consequence rather than the cause of the transformed phenotype