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May support slow-wave and REM sleep architecture, per a placebo-controlled polysomnography study in younger and older adults (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

The role of MPO and MPO-derived oxidants, particularly HOCl, in NET-mediated microbial killing will be discussed in detail later

These effects were also demonstrated in clinical trials where flavanols improved insulin sensitivity and decreased HbA1c

This study not only validates the feasibility of the mitochondrial dysfunction-induced cell death strategy, but also demonstrates the translational potential of biomimetic drug delivery systems in metabolism-targeted therapy

J.SaeedM.PallottaM.GustafsonJ

Additionally, pathologies like cancer, diabetes mellitus, cardiovascular diseases, and chronic kidney disease can cause an increase in oxidative stress