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For instance, astrocytes can significantly inhibit glutamate release by interacting with A1 receptors (A1R) and facilitating the breakdown of ATP into adenosine in the synaptic space

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Thus, any effort to intentionally alter solubility will require a modification in the chemical potentials of either the solute solid state or the solute in solution, and this approach constitutes the basis for many of the ways to enhance the solubility of drugs in a given solvent

Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, et al