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A metabolome analysis disclosed that sulphasalazine triggers an increase in the glutamate-derived TCA cycle intermediate -ketoglutarate in addition to a decrease in cysteine and glutathione

Additionally, specific cases of HGSOC exhibit overexpression of proto-oncogenes such as AKT and ERRB2

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The HPV16 E7 oncoprotein suppresses TLR9 expression through the NF-B signaling pathway, inducing an immunosuppressive state that impedes interferon production