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The FDA's 2025-2026 labeling update reinforces this picture

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Effect of glucagon-like peptide-1 receptor agonists on circulating levels of leptin and resistin: A meta-analysis of randomized controlled trials
[DOI] [PubMed] [Google Scholar] Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, et al

By week 12, the majority of patients report significant improvement in bloating as their stomach adapts to reduced portion sizes and their microbiome stabilizes

In menopausal patients, careful screening and monitoring matter even more, both to protect muscle and to catch anything that is not agreeing with you
