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counteracted muscarinic receptor agonist (pilocarpine) and antagonist (atropine)) [91,244] and adrenaline/noradrenaline-disturbances (counteracted both isoprenaline (beta agonist) and sotalol (beta antagonist) effects) [52,53] (see, Table 1, Table 2, Table 3, Table 4 and Table 5 and Figure 2)

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Curcumin-PLGA nanoparticles were administered intravenously every two days (6 doses in total), followed by LIFU-mediated BBB opening at an acoustic pressure of 0.45 MPa