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Male rats were treated with oral aripiprazole doses of 20, 40, and 60 mg/kg/day, which are 6 to 19 times the oral MRHD on mg/m2 basis, from 9 weeks prior to and through mating

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[DOI] [PMC free article] [PubMed] [Google Scholar] Paul BD, Sbodio JI, Snyder SH (2018)

Gradual titration allows assessment of individual response at each level

The role of mitochondrial DNA in mediating alveolar epithelial cell apoptosis and pulmonary fibrosis