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Rushing through titration dramatically increases side effect severity

activates sirtuins & AMPK

Some peptides stabilize neuronal membranes, reduce oxidative stress, or modulate excitotoxic signaling that kills vulnerable neurons during the recovery period

Research lacking on autophagy in glial tau

Preclinical evidence Mice with a deletion of the 22q11.2 locus containing most proteins expressed in mitochondria [19] show increased cytoplasmic 8-oxo-2-deoxyguanosine (suggesting mitochondrial DNA oxidation), reduced number of PV-immunoreactive interneurons, and weakened PNN in anterior cingulate cortex [15]

This can lead to excessive homocysteine or problems converting homocysteine into other compounds