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Elevated levels of MNAM were detected in the urine (Li et al., 2018) and serum (Souto et al., 2005) demonstrated an upregulation of NNMT expression in the WAT of individuals with IR or T2D

By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications

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doi: 10.1016/j.celrep.2016.07.027