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PLoS One 9, e101067

By inhibiting lipid ROS generation and the hyperpolarization of mitochondrial membrane potential, mitoglitazone could restore mitochondrial DNA copy number, the generation of ATP, and mitochondrial morphology in kidney tissue, inhibiting mitochondrial dysfunction and ferroptosis induced by I/R

PNPs are amphiphilic polymers self-assembled by hydrophobic interactions in aqueous solution to form a thermodynamically stable system

This condition can lead to neuropathy and CNP through a variety of mechanisms

Mitochondrial intermembrane proteins: Some proteins, like Mia40 substrates, form disulfide bonds during import and folding in the mitochondrial intermembrane space, an oxidizing compartment within the otherwise reducing intracellular environment

mAPX), cytosol (cAPX), and mitochondria (mitAPX, as a membrane-bound form