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The DOPAL-modified -syn protein can accumulate in the endo-lysosomal pathway, leading to impaired proteostasis and neurodegeneration of dopaminergic neurons both in vitro and in vivo [69]
USA 114 , E1617E1626 (2017)
Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis
For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic
These toxins bind to specific receptors that mediate their entry
