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the remaining area is the MD map (for details of this procedure, see below)

Subsequently, these metabolic products can enter the systemic circulation or be returned to the small intestine via the enterohepatic circulation

Nanobiotechnology 16:32

In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

Wang Y, Huang J-W, Calses P, Kemp CJ, Taniguchi T