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Leitch, T

TRAM (TRIF-related adapter molecule) acts as a bridge adapter between TRIF (TIR-domain-containing adapter-inducing interferon-) and TLR4

While they are frequently mentioned together, they differ significantly in origin, structure, and scientific focus

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Given the importance of the cofactor in energy metabolism, NAD + is especially important in mitochondrial function, and in fact both NAD + and mitochondria are concentrated in energetically demanding tissues 1012