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Vermeire S, Rutgeerts P: Current status of genetics research in inflammatory bowel disease

The immobilization of the enzyme arises subsequent in the development of Cross-Linked (soluble) Enzyme (CLE), Cross-Linked Enzyme Crystals (CLEC), Crosslinked Enzyme Aggregates (CLEA), and Cross-Linked Spraydrying Enzyme (CSDE) when these enzymes are placed in a medium containing a cross-linking agent [175, 176]

For example: Water depletion/dehydration can kill you, but too much water ("water Intoxication") is also lethal

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Chiddo A, Gaglione A, Musci S, et al

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