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et al., Plasma sphingolipids and lung cancer: a population-based, nested case-control study.Cancer Epidemiol Biomarkers Prev

In addition to the skin biopsy, patients should request Quantitative Sensory Testing (QST)
These include the reduced synthesis and increased excretion of the compound through the kidneys, the reduced food intake due to the low appetite and the reduced consumption of foods of animal origin

doi: 10.1111/j.1365-4632.2006.02467.x
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Research protocols investigating long-term melanocortin signaling typically employ intermittent dosing schedules for this reason