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A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70

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Lemperle G, Rullan PP, Gauthier-Hazan N

However, when accounting for within-patient clustering using a MANCOVA with patient as a fixed effect, the multivariate omnibus test was significant, and univariate effects remained significant for insomnia and end-of-dose crash, but not for poor appetite or return of symptoms

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Pitaro M, Croce N, Gallo V, Arienzo A, Salvatore G, Antonini G