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Second, when different active metabolites focus on the same target, they trigger alternations in other pathways and thus regulate other targets

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17 The formation of peroxynitrite occurs when superoxide radicals interact with nitric oxide, resulting in nitrotyrosine adducts within mitochondria

Manag Care 22:7172 Niessl C, Boulesteix AL, Oh J, Palm K, Schlingmann P, Wygoda S, Haffner D, Wuhl E, Tonshoff B, Buescher A, Billing H, Hoppe B, Zirngibl M, Kettwig M, Moeller K, Acham-Roschitz B, Arbeiter K, Bald M, Benz M, Galiano M, John-Kroegel U, Klaus G, Marx-Berger D, Moser K, Mueller D, Patzer L, Pohl M, Seitz B, Treikauskas U, von Vigier RO, Gahl WA, Hohenfellner K (2022) Relationship between age at initiation of cysteamine treatment, adherence with therapy, and glomerular kidney function in infantile nephropathic cystinosis

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Ghaiad HR, Ali SO, Al-Mokaddem AK, Abdelmonem M (2023) Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats