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Many methods for the preparation of such formulations are patented or generally known to those skilled in the art {see, e.g., Sustained and Controlled Release Drug Delivery Systems, J

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In a large randomized trial comparing four treatment strategies in 932 couples with stage I or II endometriosis or unexplained infertility, cumulative pregnancy rates during four treatment cycles were as follows: intracervical insemination (10%), intrauterine insemination (18%), gonadotropin therapy and intracervical insemination (19%), and gonadotropin therapy and intrauterine insemination (33%) (16) , (29)

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