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However, clinical trials using ibuprofen have not successfully modified AD disease progression or outcomes (91, 92), which may reflect a need for combination therapies to target multiple aspects of this complex disease

Nuclear receptor liver X receptor is O -GlcNAc-modified in response to glucose

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Based on immunohistochemical methods, aquaporin 2 ( Aqp2 ) is expressed in male germ cells, seminiferous epithelium, Leydig cells, and in the male reproductive tract (101), suggesting that Aqp2 directly or indirectly participates in male fertility