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Moreover, animal models, such as rodents, often do not accurately represent human neural systems

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Fas-associated via death domain and TNFRSF1A associated via death domain (TRADD) facilitate the recruitment of initiator caspase 8 (CASP8) or caspase 10 (CASP10), resulting in the creation of a death-inducing signaling complex and subsequent activation of procaspase

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While these findings strongly support a peripheralorigin, transorgan propagation pathway connecting renal dysfunction to PD, it is important to note that they are derived from experimental seeding models