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This work was supported, in part, by METAVIVOR Foundation Early Career Research Grant Award, the American Cancer Society Research Scholar Grant (Grant number: RSG-23-1140821-01-ET, to Q.H.), and the V Foundation Scholar Grant (to Q.H.)

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Several studies have shown that accumulating AGEs and advanced oxidation protein products (AOPPs) in humans leads to tissue destruction and dysfunction 74

Although most individuals synthesize sufficient GSH to maintain a redox balance, this is not the case in patients with PD or other neurodegenerative diseases, which has been demonstrated to be associated with GSH consumption (11)

The growthhormonereleasing peptides deepen NREM stages, whereas the antiinflammatory trio creates a calmer physiological backdrop, maximizing sleep efficiency and recovery