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Lindbergh CA, Renzi-Hammond LM, Hammond BR, et al

The aim of this narrative review is to provide a detailed and critical analysis of current knowledge about CHS

Less than 60 patients have been reported in literature of whom two were detected by NBS [95, 104]

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Nevertheless, since genotype 1 primers had been used to amplify the core region during Sanger sequencing and pangenotypic ones during NGS, it could be possible that the former ones had been able to amplify a minority population of 1b genomes that were below the NGS cut-off, i.e