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Increased Dach1 and frequency within Type R ECs at 20 months (Supplementary Figure S10), and increased levels in Type S cells (Supplementary Figure S11), is consistent with literature describing the emergence of Type R capillaries during adolescence

These proteins map to novel pathways such as integrin-linked kinase and IL-8 signaling and previously implicated pathways in sarcoidosis, including phagosome maturation, clathrin-mediated endocytic signaling and redox balance

These changes can be subtle and may not be obvious without careful observation

doi: 10.3389/fpsyt.2024.1429953 Received 09 May 2024 Accepted 24 December 2024 Published 20 February 2025 Volume 15 - 2024 Edited by Vanja Duric, Des Moines University, United States Reviewed by Lorenz S

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity
