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The studies presented other limitations, such as (a) heterogeneity, (b) varied doses and routes of melatonin administration, (c) a lack of measurement of the plasma melatonin levels for evaluation and comparison, and (d) a lack of blinding of the evaluators
Coller, Codon optimality, bias and usage in translation and mRNA decay
Serrano A
doi: 10.1016/j.bbamcr.2012.06.019
in products containing less than 2%, can cause rashes, redness, irritation, and even, paradoxically, skin darkening
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