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A: The primary factor is usually the specific research objective and the model being used

Y. Fan, Y. Gong, P. K. Ghosh, L. M. Graham, and P. L. Fox, Spatial Coordination of Actin Polymerization and ILKAkt2 Activity during Endothelial Cell Migration, Elsevier BV, May 2009. doi: 10.1016/j.devcel.2009.03.009

Neurosci Lett (2003) 335:1514

For instance, bacteria utilize amyloid pathways to increase the half-life and the spread of biofilms in human hosts or medical devices by reinforcing the robustness of their colonies

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