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In rare cases, very high doses have been linked to liver abnormalities
Bono F, De Smet F, Herbert C et al (2013) Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties
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26 Phentolamine (an alpha-adrenergic blocker) and papaverine (a nonspecific phosphodiesterase inhibitor) both act as vasodilators and may be used in combination with alprostadil if the patient has an inadequate response to alprostadil alone
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