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They established that the drug had caused non-arteritic anterior ischaemic optic neuropathy (Naion), a condition that reduces blood flow to the optic nerve, potentially leading to permanent vision loss

This is the first trial directly comparing retatrutide and tirzepatide in 800 patients under identical conditions

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Important class risks include gallbladder disease (cholelithiasis, cholecystitis) and, specifically for semaglutide in patients with type 2 diabetes, potential worsening of diabetic retinopathy complications in those with pre-existing retinopathy

Other contraindications include patients with liver failure, hematological disorders, or who are pregnant