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In each rat, two sterile sponges (1 cm x 1 cm x 0.25 cm (V=0.25 ml)) with the same quantities of NaBPC157, (solution50 g, 10 g, 10 ng/ml) or the reference agents, cimetidine (10 mg, 100 mg, 500 mg/ml), ranitidine (2.5 mg, 25 mg, 250 mg/ml), famotidine (10 mg, 50 mg, 100 mg/ml) and sucralfate (1 mg, 5 mg, 10 mg/ml) were implanted subcutaneously in the lumbar region

Plasmids CRISPRCas9 sgRNA vectors targeting 2M and ABHD11 were previously generated by the laboratory 16

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doi: 10.1111/os.13302 90 LiCYJiangLYChenWYLiKShengHQNiYet al

Introduction Cancer has emerged as a significant social, public health, and economic challenge in the 21st century

In the TMJ context, it promotes collagen remodeling of the articular disc and joint capsule, slowing degenerative changes associated with chronic mechanical loading