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Hydrolysis of palmitoyl-oleoyl-PG has been reported during surfactant injury in ARDS patient lungs 48

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What is interesting here is that transition to D-form results in exposure of a conserved cysteine residue which can be readily modified by thiol modifying reagents N-ethylmaleimide or iodoacetamide (Babot et al., 39 on Complex I subunit ND3, which forms part of the P-module, becomes exposed upon A to D transition and can then be modified by alkylating agents