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A recent preprint clinical report also suggests that clemastine enhances pyroptosis and accelerates the advance of disability in progressive MS (Kocot et al., 2024)

The endocrinology of food intake

Sci Rep 14 , 21527 (2024)

Specifically, impairments in BDNF sorting, motor recruitment to BDNF-containing vesicles, and BDNF secretion may all work in tandem to induce neuronal loss observed in HD

In accordance with theory of hormesis, we suppose that such mild, repeated stresses are responsible for adaptation of rats to subsequent stresses, e.g

In cultured somatotroph models the GHRH receptor (a class-B GPCR) couples to Gs / adenylyl cyclase, raising cAMP and activating PKA / CREB signaling associated with growth-hormone gene expression