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Injecting sterile water sans medication is a practice needing medical oversight

Both studies observed the same biphasic dose-response

Clinical trials tested weekly doses up to 12 mg for 48 weeks with manageable side effect profiles

[PubMed: 23301732] 42

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The competition between NA methylation and NAD + salvage indicates that NNMT might limit fuel oxidation and promote fat storage, because if the activity or expression of NNMT is high, then, NA might not be salvageable, thus limiting the NAD + -dependent processes [16]