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For many others, high-dose oral B12 works just as well (NIH ODS

While cobalamin overdose is unheard of because it is non-toxic and water-soluble, cobalamin deficiency can happen due to a number of reasons, including certain diseases and genetic defects.

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Jadavji N.M., Yahn G.B., Abato J.E