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Some patients report a mild headache or a feeling of lightheadedness after an IM injection

J Clin Investig 117(3):636647 Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ (2013) Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2

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Tirzepatide is a 39-amino-acid peptide with a complex structure

Higher doses do not necessarily produce better results and may increase the risk of side effects like headaches or gastrointestinal discomfort without improving fat loss outcomes