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BMP4 was up-regulated in reactive astrocytes of SOD1 ALS rat model spinal ventral horns, and BMP4 knockdown through ASO suppressed glial activation and ameliorated the motor dysfunction (Shijo et al., 2018)

indicated that in a mixed cohort of patients (both with and without type 2 DM), tirzepatide did not lead to a statistically significant increase in serious adverse events compared with placebo or other weight loss medications [12]

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PAS significantly decreased Mn levels in the body by 2533% (Zheng et al., 2009)