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doi: 10.1038/s41392-023-01604-3 46

10.1080/14712598.2020.1776255 67 HassaneinM.QianJ.HoeksemaM

Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift

Combining anti-proliferative therapy (such as rapamycin) and proapoptotic agents (statins) [24] shares that same limitation (i.e., effective only early, but not after delaying treatment)

Physical and chemical instability, quick metabolism, BBB crossing, low bioavailability, and decreased water solubility are some of the issues and limitations that natural products and isolated chemical compounds come with and can affect their therapeutic efficacy [215]

Remarkably, only the copper chelator can rescue cells from elesclomol-induced cell death