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Reconstitute with bacteriostatic water before use and store dry at -20C

It is important that there is clear guidance in the study design on what to do when adverse effects occur after sentinel dosing

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The first model is a two-layer U-shaped A 40 model (PDB ID: 2LMN), 18 while we choose a recently resolved two-layer S-shape fibril model (PDB ID:2NAO) for A 42