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An in-depth examination of the physicochemical characteristics of LNPs supports the QbD approach by identifying critical attributes, facilitating risk evaluation, directing experimental frameworks, and ensuring effective control measures

However, the demonstration that most of the vitiligo-specific features are already present in normal-appearing skin [70] suggests that cells other than melanocytes, particularly for keratinocytes and fibroblasts [71,72,73,74,75], are involved in vitiligo pathogenesis

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This broad receptor engagement profile is the defining pharmacological property that distinguishes MT-2 from the more selective MT-1