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The peptide also demonstrates notable tachyphylaxis at the pituitary level repeated dosing leads to progressively diminished GH responses, attributed to GHSR desensitization, while cardiac CD36-mediated effects appear more sustained

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Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice

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Abu-Farsakh, S., Wu, T., Lalonde, A., Sun, J