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It is to a large extent simply a matter of trial and error

MOTS-c is a mitochondrial-derived peptide that plays a key role in regulating metabolic function, enhancing fat metabolism, and improving energy levels by optimizing mitochondrial efficiency

The strategy combines resources and methods from natural product databases, anticancer drug databases, and food genomics, using artificial intelligence to design individualized anticancer dietary patterns for clinical testing

Although no functional or biochemical data are yet available for MMADHC, it is currently speculated to interact with MMACHC as part of a chaperone role to present cobalamin to the cytosolic or mitochondrial pathways (Refs 20, 62)

See Figure 2

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