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Hatmal M, Nuirat A, Zihli M, Taha M (2018) Exploring the influence of culture conditions on kefirs anticancer properties

The findings of this study suggest that toxic A peptides facilitate the oxidation of ascorbate through interactions with copper ions, leading to the production of hydroxyl radicals via the Fenton reaction (Valko et al., 2005[430]), the source of oxidative damage and neurotoxicity in the Alzheimer's disease brain
Sharaf A, De Michele R, Sharma A, Fakhari S, Obornk M (2019) Transcriptomic analysis reveals the roles of detoxification systems in response to mercury in Chromera velia

if too lipophilic, the drug is not soluble enough to cross the water layer adjacent to the cell
