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Variants of the gene MC1R that lead to a loss of function of the protein can affect the production of pheomelanin

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Tsao H, Goel V, Wu H, Yang G, Haluska FG

Where These Numbers Come From MT-2 has some human clinical data, primarily from sexual dysfunction studies rather than tanning

Bourlire, M

This syndrome, known as Hermansky-Pudlak syndrome, is inherited in an autosomal recessive manner but may have a pseudodominant inheritance in Puerto Rican families, owing to the high prevalence in this population.[112] The underlying cause is believed to be a defect in melanosome and lysosome transport