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Nrf2 is a major regulator of the cellular oxidative stress response and maintenance of redox homeostasis (Ma, 2013), and is regulated by signaling pathways such as NF-B, Notch, PI3K-AKT, and Brca-1 (Li et al., 2023a), with the PI3K/AKT signaling pathway being a sensory hair cell important regulator for survival against oxidative stress (Kucharava et al., 2019)

Furthermore, aspirin inhibits the translocation into the nucleus of cytoplasmic NF-kB (via apoptosis in outer hair cells), suggesting an additional mechanism of otoprotection [145,146]

Another well-known anti-oxidant, which is also widely used in skin care, superoxide dismutase (SOD1), gave only 20% protection [32]

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TB-4 plays a central role in building and recycling actin, one of the structural proteins cells use to move and rebuild tissue

We would also like to thank the following sponsors for sharing the data with us: This publication is based on research using data from data contributors, AbbVie, that has been made available through Vivli