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However, despite the small amount needed, the effects of a deficiency can be devastating

Environmental factors like UV exposure or pollution accelerate this by inducing more DNA damage, thus more PARP activity

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Genetic disorder can also alter the structure and production of specific enzymes which changes B 12 in coenzyme

H. Penget al., Thymosin-4prevents cardiac rupture and improves cardiac function in mice with myocardial infarction, American Physiological Society, Sep. 2014. doi: 10.1152/ajpheart.00129.2014