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Chronic activation of this pathway can lead to inflammatory disease

doi: 10.1016/S0278-6915(01)00048-5, 113

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Whilst XDHs in mammals can be converted into xanthine oxidases that produce both O 2 and H 2 O 2 , plant XDHs only form O 2 , which can be swiftly dismutated into H 2 O 2 ( 2 and H 2 O 2 at the apoplast ( 2 O 2 formation is favoured at high pH in the presence of reductants ( 2 O 2 ( For fruit tissues, however, knowledge is still lacking on the exact contribution of each source of ROS