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The support of Genevestigator team is acknowledged, too

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Clinical Worsening and Suicide Risk Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down

Cochrane Handbook for Systematic Reviews of Interventions, 205-228

Ca 2+ homeostasis The process of global Ca 2+ maintenance within the entire cell and/or sub-compartments therein

Estrogen-driven collagen decline accelerates during perimenopause, and substrate is typically already more depleted at baseline