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Glutathione synthetase deficiency is the most frequently recognized disorder and, in its severe form, it is associated with hemolytic anemia, metabolic acidosis, 5-oxoprolinuria, central nervous system (CNS) damage and recurrent bacterial infections

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Kinesiology taping targeted at supporting the tibialis posterior, flexor digitorum longs, and flexor hallucis longus has also been reported to reduce pain complaints in patients with shin splints (see figure 2.32)