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Chronic granulomatous disease: the European experience

DM is characterized by loss of glycemic control, disturbed metabolic homeostasis through deterioration of pancreatic -cell function, and insulin resistance

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PLoS Med 3:e420 Singh RK, van Haandel L, Kiptoo P, Becker ML, Siahaan TJ, Funk RS (2019) Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model

Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and interacts with the class III PI3-kinase signalling complex to positively control the formation of autophagic vacuoles 48,49
