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Patients with Lebers hereditary optic neuropathy should not receive B12 due to the risk of optic nerve damage

Post-Market Surveillance Gap: Because AOD-9604 never received FDA approval for any indication, there is no post-market surveillance system capturing safety signals from widespread clinical use

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Viechtbauer, 2010), employing a random-effect model via the metafor R package ( 3 Results 3.1 Study selection and characteristics The search strategy identified 2,183 potential articles: 1,299 from PubMed, 353 from Scopus, 527 from Embase, 4 from manual screening

doi: 10.1155/2018/5489476